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KMID : 0895820180280020021
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Journal of Oriental Rehabilitation Medicine
2018 Volume.28 No. 2 p.21 ~ p.35
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A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus
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Park Ju-Yeong
Na Yong-Su
Oh Gong-Cheon
Lee Sang-Mi
Choi Byeong-Kwon
Lee Yoon-Seung
Song Yuug-Sun
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Abstract
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Objectives: The objective of this study is to determine the antimicrobial effect of Daehwanggyeonu-san(Dahwangqianniu-san,DGE) and synergistic effects with antibiotics oxacillin, ampicillin, and gentamicin against Methicillin-Resistant Staphylococcus aureus(MRSA).
Methods: The antibacterial activity of DGE extract was evaluated againest MRSA strains by using the Disc diffusion method, broth microdilution method(minimal inhibitory concentration; MIC), checkerboard dilution test. The checkerboard dilution test was used to examined synergetic effect of oxacillin, ampicillin, gentamicin, ciprofloxacin with DGE extract.
Results: DGE showed antimicrobial activity against MRSA with an MIC value of 125∼250 μg/mL. In the checkerboard test, the interation of DGE with all tested antibiotics produced almost synergy or partial synergy against MRSA.
Conclusions: This study shows that DGE reduced the MICs of several antibiotics tested, and a remarkable antibacterial effect of DGE, with membrane permeability enhancers and ATP synthase inhibitors. This study can be a valuable source for the development of a new drug with low MRSA resistance.
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KEYWORD
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Daehwanggyeonu-san(Dahwangqianniu-san, DGE), methicillin-resistant Staphylococcus aureus(MRSA), antibacterial effect, MIC
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